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2006年09月02日

栄養療法を行う上で、重要な栄養素は数あるが、その中でも重要度の高いものがビタミンCだ。

 

ビタミンCは、食品の抗酸化剤としてさまざまな食品の添加物としても使われているし、化粧品やサプリメントとしてもよく利用されているので、私たちにとって最もなじみのあるビタミンと言えるだろう。

でもその知名度の割には、実態があまりよく知られていない栄養素No.1!かもしれない。

 

ビタミンC(一般名L-アスコルビン酸)1753年、James Lind(以下敬称略)というイギリスの海軍医により、壊血病を予防する因子として発見された。

後にハンガリーのAlbert Szent-GyorgyiがビタミンCの分離に成功し、1937年にノーベル生理医学賞を、また、化学構造の決定に成功した英国のHaworth、スイスのKarrerが同年にノーベル化学賞を受賞している。

 

しかし、ビタミンCの持つ還元作用、コラーゲン生成作用については明らかになったものの、その後の研究は1960年までほぼ停止状態だったらしい。

 

1960年代に入って、米国のIrwin Stoneが、「ヒトは遺伝的な低アスコルビン酸血症である」と述べ、ビタミンCをよりそれまで栄養学者が唱えていた量よりもはるかに多く摂取することで得られるメリットについて著した。

そしてそれが20世紀最大の科学者と言われるLinus C. Pauling(ライナス・ポーリング)を、ビタミンCの世界へと引き込んだのだ。

それは、アスコルビン酸というシンプルな化合物が持つミラクルな作用を、人類が広く知ることになる幕開けとも言えるものだった。

 

ビタミンCとは、γ-ラクトン環とエンジオール基を持つ化合物である。


 

 

ビタミンCの特徴である強い還元作用は、この構造から来ている。



 

 

線で囲んだ部分がエンジオール基で、この部分が水素供与体として働く。

この構造ゆえにOHH(水素)が引き抜かれやすいという特徴があり、電子を他の物質に与え、還元し(抗酸化)、自らは酸化される。


酸化されたビタミンCの電子はエンジオール基とラクトン環に広がって存在するため、ラジカルとしては安定し、連鎖的な酸化反応を引き起こすことはない。また、ビタミンCを再生する還元系は生体内に多数存在し、効率よく再利用される仕組みを持っている。


つまりビタミンCは、体内における水溶性の抗酸化成分として、非常に重要な役割を有している物質なのである。

 

ビタミンCの作用は、「抗酸化剤としての作用」と「水酸化酵素の補酵素としての作用」の二つに大別される。本質的にはこの両者はともに、ビタミンCの構造がもつ強力な還元作用に由来している。

 

 

ビタミンCについて述べる時、ライナス・ポーリング博士について述べないわけにはいかない。



Dr. Linus Pauling

 


ポーリング博士は分子生物学の基礎となっているタン白質の立体構造を解明した科学者であり、化学結合の研究でノーベル化学賞を、核廃絶運動でノーベル平和賞を受賞したという、ノーベル賞を二度受賞した歴史上ただ一人の人物である。

 

博士は医師ではなかったが、鎌状赤血球貧血が、ヘモグロビン分子の一本のポリペプチド鎖のアミノ酸のうちの、たった一個のアミノ酸の異常によって起きていることを解明したことでも知られている。


優れた化学者であり物理学者でもあったポーリング博士は、人体や疾患に対しても独特の鋭い視点を持っていた。

彼は多くの疾患を「分子の異常」として捉え、その分子の異常を改善することによって治療効果が得られると考えた。これが分子栄養学の始まりである。

 

彼はその晩年を、ビタミンCをはじめとする栄養素の“大量”投与(分子栄養学の立場からすると“至適量”の投与)により得られる、ガンの抑制、感染症の予防、免疫力増強、老化予防、心臓疾患の予防、白内障の予防などの様々な効果についての研究に費やし、膨大なデータを積み重ねていった。

 

しかし、天才ゆえに世間の一般常識より2歩も3歩も先を行っていたポーリング博士は、ほかに類を見ないほど偉大な科学者であったにもかかわらず、その先見性ゆえに、固定概念にとらわれた医学界からは受け入れられず、(不当に)糾弾され、爪はじきにされてしまった。

放射能が人体に及ぼす悪影響、化学療法による免疫力の低下など、今となっては常識とされていることも、博士が最初にそれらを提唱した時には、医学界の重鎮たちはこぞって否定し、博士に非難の雨アラレを降らせたのである。

 

博士の死後10年以上たった今、その業績は再評価されつつある。

 

ポーリング博士について書かれた文章を読むたびに、あまりにもすごすぎて、「この人は宇宙人だったんじゃないだろうか?」と思う私だが、ビタミンCはその博士をして、こういわしめたのである。



 

「エンジオール基が世界を救う」

 



と。

 

 

ビタミンCが有する様々な効果について、おいおい書いていきたいと思うが(こちらも見てね)、人体に有用な効果を発揮するために重要なのは、ビタミンCの「量」である。

 

かつての栄養学が目指してきた「欠乏症を防ぐ」という消極的な利用法を越えて、分子栄養学が目指しているのは、生体機能を高めるための「より進歩した」栄養素の利用法である。

至適量(従来の栄養学の所要量に比べると大量であるが、生体機能を高めるのに必要な量)のビタミンCを摂取することにより人体が浴する恩恵を理解することは、栄養療法を理解することに役立つと思う。




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コメント

こんにちわ、毎回のブログの更新楽しみにしています。
現在、中2の息子が慢性疲労の症状で悩んでおり、栄養療法を始めながらビタミンCもかかさず摂っています。子どもに説明するのは大変でこちらのブログを見て納得させています。

話は変わりますが、先日、友人が一酸化炭素による爆発で火傷をし、顔面や腕など負傷しました。この時も栄養療法が最適かと思います。たんぱく質やビタミンCが必要と考えられるのですが、アドバイスしたいのですが、うまく説明できません。何かいいアドバイスはないものでしょうか。

mitopokeさま

こんにちは!
コメントありがとうございます。
お返事遅くなりまして申し訳ありません。
息子様、大変ですね。。鉄不足などもチェックするとよいですよ。
やけどの際も栄養療法はもちろん有効です。
皮膚の再生の材料になるタン白質・ビタミンB群・亜鉛等はもちろん、活性酸素ダメージが問題となりますので、ビタミンA・C・E等を大量に補充することをお勧めします。
ビタミンCの大量点滴ができればよいと思いますけれどね。
結合組織の再生のためにコンドロイチン等も摂取するとよいですね。
治りがぜんぜん変わってくると思いますよ。
はやく回復されることを願っております。
今後ともよろしくお願いいたします。

いきなりの大量摂取は下痢などあるように思いますが、その際は少量から始めるのでかまいませんか?

活性酸素ダメージが強い場合は、相当ビタミンCを入れないと下痢しません。
適量は下痢する一歩手前の量です。(下痢しても差し支えはありません)
1gを1時間おきくらいに便が緩くなるまでとると適量がわかります。
ひどい場合は数十g飲んでも緩くなりません。
取り急ぎお返事まで。

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The new Zune browser is surprisingly good, but not as good as the iPod's. It works well, but isn't as fast as Safari, and has a clunkier interface. If you occasionally plan on using the web browser that's not an issue, but if you're planning to browse the web alot from your PMP then the iPod's larger screen and better browser may be important.

Sorry for the huge review, but I'm really loving the new Zune, and hope this, as well as the excellent reviews some other people have written, will help you decide if it's the right choice for you.

Between me and my husband we've owned more MP3 players over the years than I can count, including Sansas, iRivers, iPods (classic & touch), the Ibiza Rhapsody, etc. But, the last few years I've settled down to one line of players. Why? Because I was happy to discover how well-designed and fun to use the underappreciated (and widely mocked) Zunes are.

Sorry for the huge review, but I'm really loving the new Zune, and hope this, as well as the excellent reviews some other people have written, will help you decide if it's the right choice for you.

Hands down, Apple's app store wins by a mile. It's a huge selection of all sorts of apps vs a rather sad selection of a handful for Zune. Microsoft has plans, especially in the realm of games, but I'm not sure I'd want to bet on the future if this aspect is important to you. The iPod is a much better choice in that case.

The Zune concentrates on being a Portable Media Player. Not a web browser. Not a game machine. Maybe in the future it'll do even better in those areas, but for now it's a fantastic way to organize and listen to your music and videos, and is without peer in that regard. The iPod's strengths are its web browsing and apps. If those sound more compelling, perhaps it is your best choice.

The Zune concentrates on being a Portable Media Player. Not a web browser. Not a game machine. Maybe in the future it'll do even better in those areas, but for now it's a fantastic way to organize and listen to your music and videos, and is without peer in that regard. The iPod's strengths are its web browsing and apps. If those sound more compelling, perhaps it is your best choice.

Zune and iPod: Most people compare the Zune to the Touch, but after seeing how slim and surprisingly small and light it is, I consider it to be a rather unique hybrid that combines qualities of both the Touch and the Nano. It's very colorful and lovely OLED screen is slightly smaller than the touch screen, but the player itself feels quite a bit smaller and lighter. It weighs about 2/3 as much, and is noticeably smaller in width and height, while being just a hair thicker.

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Sorry for the huge review, but I'm really loving the new Zune, and hope this, as well as the excellent reviews some other people have written, will help you decide if it's the right choice for you.

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Between me and my husband we've owned more MP3 players over the years than I can count, including Sansas, iRivers, iPods (classic & touch), the Ibiza Rhapsody, etc. But, the last few years I've settled down to one line of players. Why? Because I was happy to discover how well-designed and fun to use the underappreciated (and widely mocked) Zunes are.

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Hands down, Apple's app store wins by a mile. It's a huge selection of all sorts of apps vs a rather sad selection of a handful for Zune. Microsoft has plans, especially in the realm of games, but I'm not sure I'd want to bet on the future if this aspect is important to you. The iPod is a much better choice in that case.

Hands down, Apple's app store wins by a mile. It's a huge selection of all sorts of apps vs a rather sad selection of a handful for Zune. Microsoft has plans, especially in the realm of games, but I'm not sure I'd want to bet on the future if this aspect is important to you. The iPod is a much better choice in that case.

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Hands down, Apple's app store wins by a mile. It's a huge selection of all sorts of apps vs a rather sad selection of a handful for Zune. Microsoft has plans, especially in the realm of games, but I'm not sure I'd want to bet on the future if this aspect is important to you. The iPod is a much better choice in that case.

I'll gear this review to 2 types of people: current Zune owners who are considering an upgrade, and people trying to decide between a Zune and an iPod. (There are other players worth considering out there, like the Sony Walkman X, but I hope this gives you enough info to make an informed decision of the Zune vs players other than the iPod line as well.)

The new Zune browser is surprisingly good, but not as good as the iPod's. It works well, but isn't as fast as Safari, and has a clunkier interface. If you occasionally plan on using the web browser that's not an issue, but if you're planning to browse the web alot from your PMP then the iPod's larger screen and better browser may be important.

The new Zune browser is surprisingly good, but not as good as the iPod's. It works well, but isn't as fast as Safari, and has a clunkier interface. If you occasionally plan on using the web browser that's not an issue, but if you're planning to browse the web alot from your PMP then the iPod's larger screen and better browser may be important.

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The Zune concentrates on being a Portable Media Player. Not a web browser. Not a game machine. Maybe in the future it'll do even better in those areas, but for now it's a fantastic way to organize and listen to your music and videos, and is without peer in that regard. The iPod's strengths are its web browsing and apps. If those sound more compelling, perhaps it is your best choice.

Apple now has Rhapsody as an app, which is a great start, but it is currently hampered by the inability to store locally on your iPod, and has a dismal 64kbps bit rate. If this changes, then it will somewhat negate this advantage for the Zune, but the 10 songs per month will still be a big plus in Zune Pass' favor.

Zune and iPod: Most people compare the Zune to the Touch, but after seeing how slim and surprisingly small and light it is, I consider it to be a rather unique hybrid that combines qualities of both the Touch and the Nano. It's very colorful and lovely OLED screen is slightly smaller than the touch screen, but the player itself feels quite a bit smaller and lighter. It weighs about 2/3 as much, and is noticeably smaller in width and height, while being just a hair thicker.

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The new Zune browser is surprisingly good, but not as good as the iPod's. It works well, but isn't as fast as Safari, and has a clunkier interface. If you occasionally plan on using the web browser that's not an issue, but if you're planning to browse the web alot from your PMP then the iPod's larger screen and better browser may be important.

Apple now has Rhapsody as an app, which is a great start, but it is currently hampered by the inability to store locally on your iPod, and has a dismal 64kbps bit rate. If this changes, then it will somewhat negate this advantage for the Zune, but the 10 songs per month will still be a big plus in Zune Pass' favor.

Sorry for the huge review, but I'm really loving the new Zune, and hope this, as well as the excellent reviews some other people have written, will help you decide if it's the right choice for you.

Sorry for the huge review, but I'm really loving the new Zune, and hope this, as well as the excellent reviews some other people have written, will help you decide if it's the right choice for you.

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I'll gear this review to 2 types of people: current Zune owners who are considering an upgrade, and people trying to decide between a Zune and an iPod. (There are other players worth considering out there, like the Sony Walkman X, but I hope this gives you enough info to make an informed decision of the Zune vs players other than the iPod line as well.)

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Zune and iPod: Most people compare the Zune to the Touch, but after seeing how slim and surprisingly small and light it is, I consider it to be a rather unique hybrid that combines qualities of both the Touch and the Nano. It's very colorful and lovely OLED screen is slightly smaller than the touch screen, but the player itself feels quite a bit smaller and lighter. It weighs about 2/3 as much, and is noticeably smaller in width and height, while being just a hair thicker.

Hands down, Apple's app store wins by a mile. It's a huge selection of all sorts of apps vs a rather sad selection of a handful for Zune. Microsoft has plans, especially in the realm of games, but I'm not sure I'd want to bet on the future if this aspect is important to you. The iPod is a much better choice in that case.

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Between me and my husband we've owned more MP3 players over the years than I can count, including Sansas, iRivers, iPods (classic & touch), the Ibiza Rhapsody, etc. But, the last few years I've settled down to one line of players. Why? Because I was happy to discover how well-designed and fun to use the underappreciated (and widely mocked) Zunes are.

Between me and my husband we've owned more MP3 players over the years than I can count, including Sansas, iRivers, iPods (classic & touch), the Ibiza Rhapsody, etc. But, the last few years I've settled down to one line of players. Why? Because I was happy to discover how well-designed and fun to use the underappreciated (and widely mocked) Zunes are.

Between me and my husband we've owned more MP3 players over the years than I can count, including Sansas, iRivers, iPods (classic & touch), the Ibiza Rhapsody, etc. But, the last few years I've settled down to one line of players. Why? Because I was happy to discover how well-designed and fun to use the underappreciated (and widely mocked) Zunes are.

The Zune concentrates on being a Portable Media Player. Not a web browser. Not a game machine. Maybe in the future it'll do even better in those areas, but for now it's a fantastic way to organize and listen to your music and videos, and is without peer in that regard. The iPod's strengths are its web browsing and apps. If those sound more compelling, perhaps it is your best choice.

Hands down, Apple's app store wins by a mile. It's a huge selection of all sorts of apps vs a rather sad selection of a handful for Zune. Microsoft has plans, especially in the realm of games, but I'm not sure I'd want to bet on the future if this aspect is important to you. The iPod is a much better choice in that case.

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The Zune concentrates on being a Portable Media Player. Not a web browser. Not a game machine. Maybe in the future it'll do even better in those areas, but for now it's a fantastic way to organize and listen to your music and videos, and is without peer in that regard. The iPod's strengths are its web browsing and apps. If those sound more compelling, perhaps it is your best choice.

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Apple now has Rhapsody as an app, which is a great start, but it is currently hampered by the inability to store locally on your iPod, and has a dismal 64kbps bit rate. If this changes, then it will somewhat negate this advantage for the Zune, but the 10 songs per month will still be a big plus in Zune Pass' favor.

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Apple now has Rhapsody as an app, which is a great start, but it is currently hampered by the inability to store locally on your iPod, and has a dismal 64kbps bit rate. If this changes, then it will somewhat negate this advantage for the Zune, but the 10 songs per month will still be a big plus in Zune Pass' favor.

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The new Zune browser is surprisingly good, but not as good as the iPod's. It works well, but isn't as fast as Safari, and has a clunkier interface. If you occasionally plan on using the web browser that's not an issue, but if you're planning to browse the web alot from your PMP then the iPod's larger screen and better browser may be important.

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原因不明の体調不良、月経前症候群、うつ症状、パニック障害、過食症、肥満…、あなたのその症状は、低血糖症が原因かもしれません!


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Optimal Health オプティマル・ヘルスとは、「最高の健康状態」を意味する言葉です。
「病気ではない」という消極的な意味での健康ではなく、エネルギーに満ちた快適な状態でいられること。
その人らしい人生を思う存分過ごすこと。
すべての患者様にOptimal Healthを得ていただくことが、私達の願いです。


未来の医者は薬を使わず、食事を重視し、病気の本来の原因を探し、予防するという、人間の基本を大切にして治療をするであろう。
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